Why RNA polymerase II translates courier RNAs?

RNA polymerase II translates courier RNAs and other minor atomic RNAs in eukaryotes. Polymerase II, similar to RNA polymerases I and III, is unequipped for acting freely. General commencement factors [transcription factor (TF) IIB, TFIID, TFIIE, TFIIF, and TFIIH] structure a massive multiprotein–DNA complex on advertiser DNA polymerase II, taking into account proper inception. Eukaryotic RNA polymerase II (pol II) is a DNA-subordinate RNA polymerase with 12 subunits that is answerable for interpreting atomic qualities that encode courier RNAs and an assortment of little atomic RN Pol III is made up of 17 subunits and is a multi-subunit complex. The catalytic site is located in the central ten-subunit nucleus, which is structurally conserved among the three eukaryotic Pols, as is the peripheral heterodimeric stalk. TFIIF-like RPC4/5 and TFIIE-like RPC3/6/7 subcomplexes are Pol III-specific. They can be thought of as “built-in” general transcription factors that play a crucial role in Pol III transcription initiation and termination2,3,4.

Pol III has a high degree of conservation in the eukaryotic kingdom, both in terms of subunit structure and sequence homology of the individual components.


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